Sedating dog acepromazine
These combinations are more effective when given i.v. Transient excitation may occur when given by this route.
When given i.m., excitation is unlikely although the depth of sedation is also reduced. Cats often require higher doses of acepromazine than dogs to achieve comparable sedation.
Low doses (1–5 μg (micrograms)/kg) of medetomidine or dexmedetomidine may be given intravenously. atipamezole at 5 times the agonist dose rate; the (unauthorized) i.v. Including opioids with medetomidine or dexmedetomidine lowers the dose required to achieve a given level of sedation, thereby limiting the marked effects that alpha-2 agonists exert on cardiopulmonary function.
The risk of excitation is proportional to the health of the recipient: the chances of producing sedation are highest (but not guaranteed) in very sick cases.
induction agent, such as alfaxalone or propofol, rather than by giving a repeated or higher dose of alpha-2 agonist. Severe depression can be antagonized using naloxone and atipamezole.
Medetomidine or dexmedetomidine, at the doses described above, can be combined with: Although xylazine (1–3 mg/kg) may be used alone or in combinations with opioids, given i.m. (unauthorized), its use in dogs and cats has been superseded by use of medetomidine or dexmedetomidine, and it is not recommended. Low doses of acepromazine (0.01 mg/kg) and medetomidine (2.5–5 μg (micrograms)/kg) or dexmedetomidine (2.5–5 μg (micrograms)/kg) combined with opioid agonist drugs provide profound sedation without signs of severe cardiopulmonary depression.
My other dog (same age, weight, breed/mut, sex) doesn't mind it at all, so I know I'm not doing anything bad to her, but at 0/trim, we're going broke getting her snipped monthly, her nails are WAY long now and I'm getting disgusted with my vet. :(Sorry that you are going through so much trouble to clip her nails.
The benedryl does cause some sedation in some dogs, in others it does nothing, especially if they are stimulated by something like clipping their nails.
Acepromazine (0.05–0.1 mg/kg) with midazolam (0.25 mg/kg) or diazepam (0.25 mg/kg) and ketamine at 2.5–7.5 mg/kg, mixed and injected i.m., provides good conditions with only modest cardiopulmonary depression.