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We find no significant rate autocorrelation among branches in three large datasets, suggesting that autocorrelated models are not necessarily suitable for these data.
In addition, we place these datasets on the continuum of clocklikeness between a strict molecular clock and the alternative unrooted extreme.
In phylogenetics, the unrooted model of phylogeny and the strict molecular clock model are two extremes of a continuum.
Despite their dominance in phylogenetic inference, it is evident that both are biologically unrealistic and that the real evolutionary process lies between these two extremes.
However, our doing so does not imply that the control measures at the Canada border have been unsuccessful.
Applying phylogeographic approaches to 289 RRV whole-genome sequences derived from isolates collected in Canada and adjacent US states, we examined the processes underlying these outbreaks.
RRV was first reported in the US state of New York in 1990.
By 1994, it had spread to reach the Canada border at Niagara in western New York, and by 1996, it had reached the New York–Ontario border at the St. Implementation of rabies vaccination started along the Niagara River in 1994 and at potential crossing points along the St.
Finally, we present analyses of 102 bacterial, 106 yeast, 61 plant, 99 metazoan, and 500 primate alignments.
From these we conclude that our method is phylogenetically more accurate and precise than the traditional unrooted model while adding the ability to infer a timescale to evolution.